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THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES.5-氟尿嘧啶及其衍生物的作用模式。
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Electron microscope study of DNA-containing plasms. II. Vegetative and mature phage DNA as compared with normal bacterial nucleoids in different physiological states.含DNA质体的电子显微镜研究。II. 营养期和成熟噬菌体DNA与处于不同生理状态的正常细菌类核的比较。
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4
Overproduction of three genes leads to camphor resistance and chromosome condensation in Escherichia coli.三种基因的过量表达导致大肠杆菌对樟脑产生抗性并出现染色体凝聚。
Genetics. 1996 Aug;143(4):1521-32. doi: 10.1093/genetics/143.4.1521.
5
Fine structure genetic map and complementation analysis of mutations in the dnaA gene of Escherichia coli.大肠杆菌dnaA基因的精细结构遗传图谱及突变互补分析
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The folded genome of Escherichia coli isolated in a protein-DNA-RNA complex.在蛋白质 - DNA - RNA 复合物中分离出的大肠杆菌折叠基因组。
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Replication of the Escherichia coli chromosome with a soluble enzyme system.用可溶性酶系统进行大肠杆菌染色体的复制。
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8
RNA molecules bound to the folded bacterial genome stabilize DNA folds and segregate domains of supercoiling.与折叠的细菌基因组结合的RNA分子可稳定DNA折叠并分离超螺旋结构域。
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Properties of a membrane-attached form of the folded chromosome of Escherichia coli.大肠杆菌折叠染色体膜附着形式的特性
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Amino acid substitutions that reduce the affinity of penicillin-binding protein 3 of Escherichia coli for cephalexin.降低大肠杆菌青霉素结合蛋白3对头孢氨苄亲和力的氨基酸替换。
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由于接触樟脑，细菌类核在体内和体外均发生解折叠。

Unfolding of the bacterial nucleoid both in vivo and in vitro as a result of exposure to camphor.

作者信息

Harrington E W, Trun N J

机构信息

Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.

出版信息

J Bacteriol. 1997 Apr;179(7):2435-9. doi: 10.1128/jb.179.7.2435-2439.1997.

DOI:10.1128/jb.179.7.2435-2439.1997
PMID:9079934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC178985/
Abstract

Both prokaryotic and eukaryotic cells are sensitive to killing by camphor; however, the mechanism by which camphor kills has not been elucidated. We report here that camphor unfolds the nucleoid of Escherichia coli and that unfolding does not require DNA replication, translation, or cell division. We show that exposure of isolated nucleoids to camphor results in unfolding of the chromosome.

摘要

原核细胞和真核细胞对樟脑的杀伤作用均敏感；然而，樟脑的杀伤机制尚未阐明。我们在此报告，樟脑可使大肠杆菌的类核解折叠，且这种解折叠不需要DNA复制、翻译或细胞分裂。我们表明，将分离的类核暴露于樟脑会导致染色体解折叠。