由于接触樟脑，细菌类核在体内和体外均发生解折叠。
Unfolding of the bacterial nucleoid both in vivo and in vitro as a result of exposure to camphor.
作者信息
Harrington E W, Trun N J
机构信息
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.
出版信息
J Bacteriol. 1997 Apr;179(7):2435-9. doi: 10.1128/jb.179.7.2435-2439.1997.
Abstract
Both prokaryotic and eukaryotic cells are sensitive to killing by camphor; however, the mechanism by which camphor kills has not been elucidated. We report here that camphor unfolds the nucleoid of Escherichia coli and that unfolding does not require DNA replication, translation, or cell division. We show that exposure of isolated nucleoids to camphor results in unfolding of the chromosome.
摘要
原核细胞和真核细胞对樟脑的杀伤作用均敏感；然而，樟脑的杀伤机制尚未阐明。我们在此报告，樟脑可使大肠杆菌的类核解折叠，且这种解折叠不需要DNA复制、翻译或细胞分裂。我们表明，将分离的类核暴露于樟脑会导致染色体解折叠。
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