Tsuchie H, Oda K, Vythilingam I, Thayan R, Vijayamalar B, Sinniah M, Singh J, Wada T, Tanaka H, Kurimura T, Igarashi A
Research Institute for Microbial Diseases, Osaka University, Japan.
Am J Trop Med Hyg. 1997 Feb;56(2):153-8. doi: 10.4269/ajtmh.1997.56.153.
Two hundred forty nucleotides from the pre-membrane gene region of 12 Japanese encephalitis virus (JEV) strains isolated from three different regions of Malaysia from 1993 to 1994 were sequenced and compared with each other and with the JEV strains from different geographic areas in Asia. These 12 Malaysian isolates were classified into two genotypes. The four JEV strains isolated from Sarawak in 1994 and the four JEV strains isolated from Sepang, Selangor in 1993 were classified into one genotype that included earlier isolated strains from Malaysia (JE-827 from Sarawak in 1968 and WTP/70/22 from Kuala Lumpur in 1970). The four JEV strains from Ipoh, Perak in 1994 were classified into another genotype that included JEV strains isolated from northern Thailand and Cambodia. In an earlier report, 10 JEV strains from Sabak Bernam, Selangor in 1992 were classified into the largest genotype that included strains isolated in temperate regions such as Japan, China, and Taiwan. The data indicate that at least three genotypes of JEV have been circulating in Malaysia.
对1993年至1994年从马来西亚三个不同地区分离出的12株日本脑炎病毒（JEV）前膜基因区域的240个核苷酸进行了测序，并相互比较，同时与来自亚洲不同地理区域的JEV毒株进行了比较。这12株马来西亚分离株被分为两种基因型。1994年从砂拉越分离出的4株JEV毒株和1993年从雪兰莪州士邦分离出的4株JEV毒株被归为一种基因型，该基因型还包括马来西亚早期分离出的毒株（1968年来自砂拉越的JE - 827和1970年来自吉隆坡的WTP/70/22）。1994年从霹雳州怡保分离出的4株JEV毒株被归为另一种基因型，该基因型包括从泰国北部和柬埔寨分离出的JEV毒株。在一份早期报告中，1992年从雪兰莪州实兆远分离出的10株JEV毒株被归为最大的基因型，该基因型包括在日本、中国和台湾等温带地区分离出的毒株。数据表明，至少三种基因型的JEV在马来西亚传播。
