Cerpa-Poljak A, Lahnstein J, Mason K E, Smythe G A, Duncan M W
Cooperative Research Centre for Biopharmaceutical Research, Darlinghurst, Australia.
J Neurochem. 1997 Apr;68(4):1712-9. doi: 10.1046/j.1471-4159.1997.68041712.x.
The hemorphins are a family of recently identified opioid receptor binding peptides derived from the proteolytic processing of the beta, gamma, delta, and epsilon chains of hemoglobin. They have previously been identified at high concentration in human pituitary glands and in the CSF of patients with cerebral bleeding. Hemorphins are potent inhibitors of angiotensin converting enzyme and therefore possibly have a role to play in blood pressure regulation. We report the presence of four hemorphin peptides in extracts of normal adrenal tissue and in pheochromocytoma tumors. The hemorphins were quantified and structurally characterized using mass spectrometry. High concentrations of hemorphins were found in all samples, comparable with the levels reported in the literature for pituitary and brain tissue.
血啡肽是最近发现的一类阿片受体结合肽家族，由血红蛋白的β、γ、δ和ε链经蛋白水解加工而成。此前已在人垂体以及脑出血患者的脑脊液中发现其高浓度存在。血啡肽是血管紧张素转换酶的强效抑制剂，因此可能在血压调节中发挥作用。我们报告在正常肾上腺组织提取物和嗜铬细胞瘤肿瘤中存在四种血啡肽肽。使用质谱对血啡肽进行了定量和结构表征。在所有样本中均发现高浓度的血啡肽，与文献报道的垂体和脑组织中的水平相当。
