Cuellar M J, Giner R M, Recio M C, Just M J, Mañez S, Rios J L
Departament de Farmacologia, Facultat de Farmacia, Universitat de València, Spain.
Chem Pharm Bull (Tokyo). 1997 Mar;45(3):492-4. doi: 10.1248/cpb.45.492.
The hydroalcoholic extract from P. cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic inflammation and oxazolone delayed hypersensitivity in mice. Two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. Their ID50 on acute TPA edema was 4.7 x 10(-3) and 6.8 x 10(-4) mumol/ear, respectively.
对茯苓水醇提取物进行了口服和局部抗炎活性研究。结果证明其对角叉菜胶、花生四烯酸、十四酰佛波醇乙酸酯（TPA）诱导的急性水肿、TPA诱导的慢性炎症以及恶唑酮诱导的小鼠迟发型超敏反应均有活性。通过光谱法分离并鉴定出两种羊毛甾烷型三萜，分别为脱氢茯苓酸和茯苓酸。它们对TPA诱导的急性水肿的半数抑制剂量（ID50）分别为4.7×10⁻³和6.8×10⁻⁴ μmol/耳。
