Yasukawa K, Kaminaga T, Kitanaka S, Tai T, Nunoura Y, Natori S, Takido M
College of Pharmacy, Nihon University, Chiba, Japan.
Phytochemistry. 1998 Aug;48(8):1357-60. doi: 10.1016/s0031-9422(97)01063-7.
The structure of a new triterpene derivative isolated from Poria cocos was determined to be 3 beta-p-hydroxybenzoyldehydrotumulosic acid by spectral and chemical methods. 3 beta-p-hydroxybenzoyldehydrotumulosic acid showed marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)- and arachidonic acid (AA)-induced ear inflammation in mice. The 50% inhibitory doses of 3 beta-p-hydroxybenzoyldehydrotumulosic acid were 0.27 and 1.25 mg per ear on TPA- and AA-induced inflammation, respectively.
通过光谱和化学方法确定，从茯苓中分离出的一种新的三萜衍生物的结构为3β - 对羟基苯甲酰脱氢土莫酸。3β - 对羟基苯甲酰脱氢土莫酸对12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）和花生四烯酸（AA）诱导的小鼠耳部炎症表现出显著的抑制活性。3β - 对羟基苯甲酰脱氢土莫酸对TPA和AA诱导炎症的50%抑制剂量分别为每只耳朵0.27毫克和1.25毫克。
