Yanai H, Nishikawa J, Mizugaki Y, Shimizu N, Takada K, Matsusaki K, Toda T, Matsumoto Y, Tada M, Okita K
First Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Gastrointest Endosc. 1997 Mar;45(3):236-42. doi: 10.1016/s0016-5107(97)70265-7.
Although the presence of Epstein-Barr virus has been documented in approximately 7% of patients with gastric carcinoma, the clinical features of Epstein-Barr virus-associated carcinoma have not been well documented. We studied the histologic and endoscopic characteristics of Epstein-Barr virus-associated gastric carcinoma.
We tested 124 gastric carcinomas from 117 patients using in situ hybridization for Epstein-Barr virus encoded small RNA1. The histologic and endoscopic findings in the Epstein-Barr virus-associated groups and the negative control groups were analyzed and compared.
Twelve tumors (9.7%) were identified as Epstein-Barr virus associated. These lesions were located mainly in the upper part of the stomach (p < .05) and had a diffuse-type histology (p < .05) compared with those in the control group. Six of seven (85.7%) early Epstein-Barr virus-associated lesions were type 0 IIc (superficial depressed) or a combined type, and 42.9% were accompanied by submucosal nodules of carcinoma with lymphoid stroma. Four of five (80%) advanced Epstein-Barr virus-associated tumors were type 3 (ulcerated without definite limits), thought to be the advanced shape of superficial depressed lesions.
Epstein-Barr virus-associated gastric carcinomas often appear as superficial depressed or ulcerated lesions in the upper part of the stomach and have a diffuse-type histology with lymphoid infiltration.
尽管在约7%的胃癌患者中已证实存在爱泼斯坦-巴尔病毒，但爱泼斯坦-巴尔病毒相关癌的临床特征尚未得到充分记录。我们研究了爱泼斯坦-巴尔病毒相关胃癌的组织学和内镜特征。
我们对117例患者的124例胃癌进行了原位杂交检测，以检测爱泼斯坦-巴尔病毒编码的小RNA1。对爱泼斯坦-巴尔病毒相关组和阴性对照组的组织学和内镜检查结果进行了分析和比较。
12例肿瘤（9.7%）被确定为爱泼斯坦-巴尔病毒相关。与对照组相比，这些病变主要位于胃上部（p<0.05），组织学类型为弥漫型（p<0.05）。7例早期爱泼斯坦-巴尔病毒相关病变中有6例（85.7%）为0 IIc型（浅表凹陷型）或混合型，42.9%伴有癌性黏膜下结节及淋巴间质。5例进展期爱泼斯坦-巴尔病毒相关肿瘤中有4例（80%）为3型（无明确界限的溃疡型），被认为是浅表凹陷性病变的进展形态。
爱泼斯坦-巴尔病毒相关胃癌常表现为胃上部的浅表凹陷或溃疡病变，组织学类型为弥漫型并伴有淋巴浸润。
