McClearn G E
Center for Developmental and Health Genetics, Pennsylvania State University, University Park 16802, USA.
Exp Gerontol. 1997 Jan-Apr;32(1-2):87-94. doi: 10.1016/s0531-5565(96)00067-8.
The escalating interest in research on interventions that may affect aging processes has necessarily focussed attention on the outcome measures. The desirable characteristics of these "biomarker variables" have been widely discussed. This article offers some reflections on validity, reliability, and generalizability of biomarkers. It is argued that our comprehension of aging will evolve iteratively from application of a diversity of biomarker variables. Each of these will have strengths and shortcomings from methodological and measurement points of view. The siren song that a "gold standard" index of aging can be found should be ignored.
对可能影响衰老过程的干预措施研究兴趣的不断升级，必然将注意力集中在了结果指标上。这些“生物标志物变量”的理想特征已得到广泛讨论。本文对生物标志物的有效性、可靠性和普遍性进行了一些思考。有人认为，我们对衰老的理解将通过应用多种生物标志物变量而迭代发展。从方法学和测量的角度来看，每一种变量都有其优缺点。那种认为能够找到衰老的“金标准”指标的诱人说法应该被忽略。
