Sprott R L
Biology of Aging Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
Exp Gerontol. 1997 Jan-Apr;32(1-2):205-14. doi: 10.1016/s0531-5565(96)00065-4.
Current data suggest that the life spans of commonly held rodent species have decreased and the occurrence of tumors occurs earlier in the lifespan of ad libitum-fed animals. The most likely cause of this change in the life span of barrier-reared genetically defined animals is increased body weight. The effects of caloric restriction on a variety of functional measures and on age-dependent tumors and lesions are the focus of this presentation. Recommendations for caloric restriction, or at least "dietary control," will be discussed.
目前的数据表明，常见啮齿动物物种的寿命缩短，且在自由采食动物的寿命中肿瘤出现得更早。屏障饲养的基因定义动物寿命发生这种变化的最可能原因是体重增加。热量限制对各种功能指标以及对年龄相关肿瘤和病变的影响是本报告的重点。将讨论热量限制的建议，或者至少是“饮食控制”的建议。
