Durand G M, Konnerth A
I. Physiologisches Institut der Universität des Saarlandes, Homburg, Germany.
J Physiol Paris. 1996;90(5-6):313-5. doi: 10.1016/s0928-4257(97)87905-3.
During the first 2 days of postnatal development, CA1 hippocampal glutamatergic synaptic transmission is based almost exclusively on NMDA receptors and is non-functional at resting potential. Within the following days an increasing number of functionally mature synapses, containing both NMDA and AMPA receptors, were observed. We found that the maturation of the NMDA receptor-mediated synapses could be induced experimentally with a pairing protocol, a process termed functional synapse induction. Our data provide evidence that a LTP-like mechanism involved in the activity-dependent formation of functional glutamergic synapses in the developing hippocampus.
在出生后发育的前两天，CA1海马谷氨酸能突触传递几乎完全基于NMDA受体，并且在静息电位时无功能。在接下来的几天里，观察到越来越多功能成熟的突触，其中同时含有NMDA和AMPA受体。我们发现，NMDA受体介导的突触成熟可以通过配对方案实验性诱导，这一过程称为功能性突触诱导。我们的数据提供了证据，表明一种类似长时程增强（LTP）的机制参与了发育中海马体中功能性谷氨酸能突触的活动依赖性形成。
