Ohtsuki C, Iida H, Hayakawa S, Osaka A
Biomaterials Laboratory, Faculty of Engineering, Okayama University, Japan.
J Biomed Mater Res. 1997 Apr;35(1):39-47. doi: 10.1002/(sici)1097-4636(199704)35:1<39::aid-jbm5>3.0.co;2-n.
Commercially available pure metallic titanium was chemically treated at 60 degrees C for 24 h with H2O2 solutions containing various metal chlorides to provide titanium with bioactivity, that is, to give it the ability to form a biologically active bone-like apatite layer on the surface. After the chemical treatment the titanium specimens were soaked in a simulated body fluid (the Kokubo solution). Apatite was found to deposit on the specimens treated with the H2O2/TaCl5 and H2O2/SnCl2 solutions. X-ray photoelectron spectroscopic (XPS) study of the specimens treated with those H2O2 solutions indicated that basic Ti-OH groups in titania hydrogel layers on their surfaces were responsible for apatite nucleation and growth.
将市售的纯金属钛在60℃下用含有各种金属氯化物的过氧化氢溶液进行化学处理24小时，以使钛具有生物活性，即赋予其在表面形成具有生物活性的骨样磷灰石层的能力。化学处理后，将钛样品浸泡在模拟体液（Kokubo溶液）中。发现磷灰石沉积在用H2O2/TaCl5和H2O2/SnCl2溶液处理过的样品上。对用这些过氧化氢溶液处理过的样品进行的X射线光电子能谱（XPS）研究表明，其表面二氧化钛水凝胶层中的碱性Ti-OH基团是磷灰石成核和生长的原因。
