Gniadecka M, Lock-Andersen J, de Fine Olivarius F, Wulf H C
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Denmark.
Photodermatol Photoimmunol Photomed. 1996 Oct;12(5):189-93. doi: 10.1111/j.1600-0781.1996.tb00198.x.
The degree of erythema following UV irradiation is known to depend upon skin temperature at the time of UV exposure. We investigated whether changes in skin temperature at the time of erythema assessment influenced the level of erythema. Twenty-two healthy people (mean age 26 years) were irradiated with solar stimulated radiation on previously UV un-exposed buttock skin. The erythematous reactions were evaluated 20-24 h after irradiation by visual scoring and by measurements of skin reflectance and laser Doppler flowmetry. The readings were done at the baseline level at 21 degrees C room temperature where skin temperature was 30.0 +/- 1.7 degrees C and subsequently after skin warming to 37.2 +/- 2.5 degrees C and after cooling to 22.8 +/- 2.6 degrees C. After skin warming, a clinically evaluated erythema grade [0, (+), +, ++, + + +] was scored higher for at least one reaction in 10 of 22 individuals (45%). In the same proportion of subjects, changes to lower erythema grades were detected upon cooling. Skin warming caused an increase in laser Doppler blood flux, but skin cooling did not have a significant effect on cutaneous perfusion. Skin redness measured by skin reflectance was relatively stable during the cooling phase, but a significant increase in skin redness was noted for 0 reaction upon skin warming. For ++ and + + + reactions a small but significance decrease in reflectance was noted. Our results indicate that alterations in skin temperature, especially a temperature increase, modulates the degree of UV-induced erythema moderately. The temperature-dependent changes as an assessment of the (+) reaction are of practical significance, since this reaction is used for the assessment of cutaneous photosensitivity.
已知紫外线照射后的红斑程度取决于紫外线暴露时的皮肤温度。我们研究了红斑评估时皮肤温度的变化是否会影响红斑水平。22名健康人（平均年龄26岁）的臀部皮肤此前未暴露于紫外线，现接受太阳模拟辐射照射。照射后20 - 24小时，通过视觉评分、皮肤反射率测量和激光多普勒血流仪评估红斑反应。读数在室温21摄氏度的基线水平进行，此时皮肤温度为30.0±1.7摄氏度，随后在皮肤升温至37.2±2.5摄氏度以及降温至22.8±2.6摄氏度后进行。皮肤升温后，22名个体中有10名（45%）至少有一项反应的临床评估红斑等级[0, (+), +, ++, + + +]得分更高。在相同比例的受试者中，降温后红斑等级降低。皮肤升温导致激光多普勒血流增加，但皮肤降温对皮肤灌注没有显著影响。在降温阶段，通过皮肤反射率测量的皮肤发红相对稳定，但皮肤升温后0级反应的皮肤发红显著增加。对于++和 + + +级反应，反射率有小幅但显著的下降。我们的结果表明，皮肤温度的改变，尤其是温度升高，会适度调节紫外线诱导的红斑程度。温度依赖性变化作为对(+)反应的评估具有实际意义，因为该反应用于评估皮肤光敏性。
