Kuo Y H, Kuo L M
National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C.
Phytochemistry. 1997 Apr;44(7):1275-81. doi: 10.1016/s0031-9422(96)00719-4.
Four new triterpene compounds, celasdin-A, celasdin-C, anti-AIDS celasdin-B and cytotoxic maytenfolone-A, were isolated from Celastrus hindsii. The structural determination of maytenfolone-A, celasdin-A, celasdin-B and celasdin-C, as well as the structure-activity relationships of these new compounds and derivatives, are discussed. Maytenfolone-A was further confirmed by X-ray studies. Biological evaluation showed that Maytenfolone-A demonstrated cytotoxicity against hepatoma (HEPA-2B, ED50 = 2.3 micrograms ml-1) and nasopharynx carcinoma (KB, ED50 = 3.8 micrograms ml-1). Celasdin-B was found to exhibit anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 0.8 microgram ml-1).
从南蛇藤中分离出了四种新的三萜类化合物，即南蛇藤素A、南蛇藤素C、抗艾滋病南蛇藤素B和具有细胞毒性的美登木素A。讨论了美登木素A、南蛇藤素A、南蛇藤素B和南蛇藤素C的结构测定，以及这些新化合物及其衍生物的构效关系。美登木素A通过X射线研究得到了进一步证实。生物学评价表明，美登木素A对肝癌（HEPA-2B，半数有效剂量=2.3微克/毫升）和鼻咽癌（KB，半数有效剂量=3.8微克/毫升）具有细胞毒性。发现南蛇藤素B在H9淋巴细胞中具有抗HIV复制活性，半数有效浓度为0.8微克/毫升。
