细胞毒性药物对人结肠肿瘤异种移植中胸苷掺入及生长延迟的影响。
Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.
作者信息
Houghton P J, Houghton J A, Taylor D M
出版信息
Br J Cancer. 1977 Aug;36(2):206-14. doi: 10.1038/bjc.1977.179.
Abstract
The relationship between the utilization of 3H-thymidine in situ ([3H]-TdR fractional incorporation or TFI) and tumour growth delay after treatment with various cytotoxic agents has been examined. It is shown that (a) it is not possible to predict tumour growth delay, or to select the most effective agent, from changes in TFI 1 day after treatment; (b) there is a good correlation between tumour growth delay and the time for recovery of TFI to the pretreatment level; (c) there is a relationship within a tumour line between the depression of TFI 4 days after treatment and growth dealy induced by the same treatment. This relationship appears to be independent of the mechanism by which the agent exerts its cytotoxic effect.
摘要
研究了用各种细胞毒性药物治疗后，原位3H-胸腺嘧啶核苷的利用情况（[3H]-TdR分数掺入或TFI）与肿瘤生长延迟之间的关系。结果表明：（a）治疗后1天TFI的变化无法预测肿瘤生长延迟，也无法选择最有效的药物；（b）肿瘤生长延迟与TFI恢复到治疗前水平的时间之间存在良好的相关性；（c）在同一肿瘤系中，治疗后4天TFI的降低与同一治疗诱导的生长延迟之间存在关系。这种关系似乎与药物发挥细胞毒性作用的机制无关。
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