Longstreth G F, Wolde-Tsadik G
Department of Medicine, Southern California Permanente Medical Group, San Diego.
Dig Dis Sci. 1993 Sep;38(9):1581-9. doi: 10.1007/BF01303163.
A study of irritable bowel-type symptoms in 1264 health examinees using a self-administered questionnaire and psychological tests revealed they are common throughout adulthood. Of affected subjects 68% were female, and those with the more severe type (> or = 3 Manning criteria) were predominantly female (80%). Fewer Asians than other racial/ethnic groups had these symptoms. Nongastrointestinal symptoms, physician visits, incontinence, laxative use, a stress effect on bowel pattern and abdominal pain, abdominal surgery, hysterectomy, childhood abuse, use of mind-altering drugs, depression, and anxiety were correlated with irritable bowel-type symptoms. Regression analysis found some of the clinical correlates were independent markers for irritable bowel-type symptoms and that sexual abuse was related to nongastrointestinal symptoms and abdominal surgery independent of irritable bowel-type symptoms. More severe irritable bowel-type symptoms were especially associated with nongastrointestinal symptoms, stress effects, sexual abuse, use of sedatives and oral narcotics, and a past alcohol problem. There are important demographic and clinical correlates with irritable bowel-type symptoms.
一项针对1264名健康体检者的研究，通过自我管理问卷和心理测试对肠易激综合征类型症状进行调查，结果显示这些症状在整个成年期都很常见。在受影响的受试者中，68%为女性，而症状较严重（曼宁标准≥3项）的患者中女性占主导（80%）。与其他种族/族裔群体相比，亚洲人出现这些症状的比例较低。非胃肠道症状、就医次数、大小便失禁、使用泻药、压力对排便习惯和腹痛的影响、腹部手术、子宫切除术、童年期受虐、使用精神类药物、抑郁和焦虑与肠易激综合征类型症状相关。回归分析发现，一些临床相关因素是肠易激综合征类型症状的独立标志物，并且性虐待与非胃肠道症状和腹部手术相关，独立于肠易激综合征类型症状。更严重的肠易激综合征类型症状尤其与非胃肠道症状、压力影响、性虐待、使用镇静剂和口服麻醉剂以及过去的酒精问题有关。肠易激综合征类型症状存在重要的人口统计学和临床相关因素。
