Creinin M D
University of Pittsburgh School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Women's Hospital, USA.
Hum Reprod. 1997 Mar;12(3):496-8. doi: 10.1093/humrep/12.3.496.
This review discusses the available data reporting the efficacy of emergency contraceptive treatment with the Yuzpe regimen (0.2 mg of ethinyl oestradiol in combination with either 2.0 mg of norgestrel or 1.0 mg of levonorgestrel) and evaluates the true effectiveness in preventing pregnancy. A literature review was completed for reports including women treated with the Yuzpe using a MEDLINE search for articles published since 1970 and by reviewing the secondary reference lists of these manuscripts. Expected pregnancy rates for each study population were calculated using published conception rate estimates. Seven published studies provided adequate data to assess accurately efficacy of the Yuzpe regimen in preventing pregnancy after unprotected intercourse. Of 2871 women treated, 54 (1.9%, 95% confidence intervals (CI) 1.4-2.4) became pregnant. By calculating the expected pregnancy rates using two different methodologies, the Yuzpe regimen decreased the observed number of pregnancies by 70.0% (95% CI 63.3-76.7) and 77.2% (95% CI 71.5-82.8). Emergency contraception with the Yuzpe regimen is an effective form of contraception to prevent unwanted pregnancy after unprotected intercourse.
本综述讨论了有关使用Yuzpe方案（0.2毫克炔雌醇与2.0毫克炔诺孕酮或1.0毫克左炔诺孕酮联合使用）进行紧急避孕治疗疗效的现有数据，并评估了其预防妊娠的实际效果。通过对MEDLINE数据库进行检索，查找自1970年以来发表的文章，并查阅这些手稿的参考文献列表，完成了一项关于接受Yuzpe方案治疗女性的文献综述。使用已发表的受孕率估计值计算每个研究人群的预期妊娠率。七项已发表的研究提供了足够的数据，以准确评估Yuzpe方案在无保护性交后预防妊娠的疗效。在接受治疗的2871名女性中，有54名（1.9%，95%置信区间（CI）1.4 - 2.4）怀孕。通过使用两种不同方法计算预期妊娠率，Yuzpe方案使观察到的妊娠数减少了70.0%（95% CI 63.3 - 76.7）和77.2%（95% CI 71.5 - 82.8）。采用Yuzpe方案进行紧急避孕是一种有效的避孕方式，可预防无保护性交后意外怀孕。
