Atkins B L, Price E H, Tillyer L, Novelli V, Evans J
Microbiology Department, Royal London Hospital, Whitechapel, U.K.
J Infect. 1997 Mar;34(2):133-8. doi: 10.1016/s0163-4453(97)92452-x.
Five cases of Salmonella osteomyelitis are presented in children with sickle cell disease living in the East End of London. Four of these had involvement of the long bones and one (an infant) presented with hand-foot syndrome. Four required surgical drainage of pus and all required lengthy therapy with antibiotics. Factors contributing to the increased susceptibility of these patients to invasive disease with Salmonella sp. are discussed as are the clinical features, surgical and antibiotic management and possible preventative measures.
本文介绍了5例居住在伦敦东区患有镰状细胞病的儿童沙门氏菌骨髓炎病例。其中4例累及长骨，1例（婴儿）表现为手足综合征。4例需要手术引流脓液，所有病例均需要长期使用抗生素治疗。文中讨论了导致这些患者对沙门氏菌属侵袭性疾病易感性增加的因素、临床特征、手术及抗生素治疗以及可能的预防措施。
