He K, Shi G, Zeng L, Ye Q, McLaughlin J L
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
Planta Med. 1997 Apr;63(2):158-60. doi: 10.1055/s-2006-957635.
Three sesquiterpenes, konishiol (1), cadalenol (2), 3-cedranol (3), one diterpene, manool (4), and one lignan, (+)-tsugacetal (5), have been isolated, for the first time, from the whole plant of Cunninghamia konishii by using bioactivity-directed fractionation. Compound 1 is new to the literature, and its chemical structure was determined by various spectroscopic analyses including EIMS, HREIMS, NOE, NOESY, and by preparing its di-acetyl derivative (1a). Compounds 2-5 showed moderate to weak bioactivities in brine shrimp (BST) and mosquito larvae (YFM) bioassays as well as cytotoxicities against three human solid tumor cell lines.
通过生物活性导向分离法，首次从台湾杉全株中分离出三种倍半萜，即小西醇（1）、卡达烯醇（2）、3-雪松醇（3），一种二萜，马尼醇（4），以及一种木脂素，（+）-穗花杉双黄酮（5）。化合物1是文献中首次报道的新化合物，其化学结构通过包括电子轰击质谱（EIMS）、高分辨电子轰击质谱（HREIMS）、核Overhauser效应（NOE）、二维核Overhauser效应谱（NOESY）等各种光谱分析方法，并通过制备其二乙酰衍生物（1a）得以确定。化合物2-5在卤虫（BST）和蚊虫幼虫（YFM）生物测定中显示出中等至较弱的生物活性，以及对三种人类实体瘤细胞系的细胞毒性。
