Bushara K O
Department of Neurology, University of Wisconsin Hospital and Clinics, Madison 53792, USA.
Med Hypotheses. 1997 Apr;48(4):337-9. doi: 10.1016/s0306-9877(97)90103-1.
The inhibitory action of botulinum toxin is not confined to the neuromuscular junction. The toxin has long been known to block all the autonomic cholinergic fibers, including the major secretomotor parasympathetic fibers to salivary glands. The parotids are the largest of the salivary glands and their selective chemodenervation with botulinum toxin A is likely to result in substantial reduction of saliva production. Injection of the parotid glands with botulinum toxin is proposed as an new treatment for sialorrhea in patients with amyotrophic lateral sclerosis and other neurological diseases.
肉毒杆菌毒素的抑制作用并不局限于神经肌肉接头。长期以来人们已知该毒素会阻断所有自主胆碱能纤维，包括支配唾液腺的主要分泌运动副交感纤维。腮腺是最大的唾液腺，用A型肉毒杆菌毒素对其进行选择性化学去神经支配可能会导致唾液分泌大幅减少。向腮腺注射肉毒杆菌毒素被提议作为治疗肌萎缩侧索硬化症和其他神经疾病患者流涎的一种新疗法。
