Takahashi Y, Tucker S L, Kitadai Y, Koura A N, Bucana C D, Cleary K R, Ellis L M
Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, USA.
Arch Surg. 1997 May;132(5):541-6. doi: 10.1001/archsurg.1997.01430290087018.
The value of these prognostic factors was compared with that of other clinicopathologic factors such as tumor grade, tumor stage, mucin production, vascular invasion, perineural invasion, and lymphatic invasion.
To determine whether the development of distant recurrence in patients with node-negative colon cancer could be predicted using vessel count and vascular endothelial growth factor (VEGF) expression.
Paraffin-embedded colon cancers were immunostained for factor VIII, VEGF, basic fibroblast growth factor, and proliferating cell nuclear antigen; slides were reviewed for differentiation, mucin production, and the presence of vascular, lymphatic, and/or perineural invasion.
A large academic cancer referral center where 27 patients with node-negative colon cancer were operated on during 1988 and 1989.
The development of and interval to recurrence.
Eight patients developed liver, lung, or lymph node metastases at a median of 24 months. The median follow-up for patients without cancer recurrence was 60 months. The mean tumor vessel count for those patients who remained disease-free was significantly fewer than for those patients who suffered a recurrence (20 vs 33, respectively). By univariate analysis, 3 factors- perineural invasion, vessel count, and VEGF expression- were correlated with time to recurrence. By multivariate analysis, only vessel count was significantly related to differences in time to recurrence. Expression of VEGF correlated with vessel count.
Vessel count and expression of VEGF may be useful for predicting distant recurrence in patients with node-negative colon cancer.
将这些预后因素的价值与其他临床病理因素进行比较，如肿瘤分级、肿瘤分期、黏液产生、血管侵犯、神经周围侵犯和淋巴侵犯。
确定使用血管计数和血管内皮生长因子（VEGF）表达是否可以预测无淋巴结转移结肠癌患者远处复发的发生情况。
对石蜡包埋的结肠癌进行免疫染色，检测因子VIII、VEGF、碱性成纤维细胞生长因子和增殖细胞核抗原；对切片进行评估，以确定分化程度、黏液产生情况以及是否存在血管、淋巴和/或神经周围侵犯。
一家大型学术性癌症转诊中心，1988年至1989年期间对27例无淋巴结转移的结肠癌患者进行了手术。
复发的发生情况及复发间隔时间。
8例患者出现肝、肺或淋巴结转移，中位时间为24个月。无癌症复发患者的中位随访时间为60个月。无疾病复发患者的平均肿瘤血管计数明显少于复发患者（分别为20和33）。单因素分析显示，3个因素——神经周围侵犯、血管计数和VEGF表达——与复发时间相关。多因素分析显示，只有血管计数与复发时间的差异显著相关。VEGF表达与血管计数相关。
血管计数和VEGF表达可能有助于预测无淋巴结转移结肠癌患者的远处复发。
