Drewnowski A, Rock C L, Henderson S A, Shore A B, Fischler C, Galan P, Preziosi P, Hercberg S
Human Nutrition Program, School of Public Health, University of Michigan, Ann Arbor 48109-2029, USA.
Am J Clin Nutr. 1997 Jun;65(6):1796-802. doi: 10.1093/ajcn/65.6.1796.
Relatively high intakes of vegetables and fruit and relatively low intakes of fat are associated with lower rates of heart disease and many types of cancer. Biomarkers for vegetable and fruit consumption are most useful when applicable across different ages, body weights, diets, and varying patterns of fat intake. This study examined two biomarkers, serum concentrations of beta-carotene and vitamin C, as a function of anthropometric, dietary, and lifestyle factors in a community-based sample of French adults. The interview-based dietary-history method was used to assess dietary intakes of 361 males and 476 females aged 18-94 y resident in the Val-de-Marne district southeast of Paris. Serum beta-carotene was quantified by HPLC and vitamin C was measured by using an automated method. Serum beta-carotene and vitamin C concentrations were positively associated with vegetable and fruit intakes and were negatively linked to the consumption of energy, alcohol, and fat. Multiple-regression analyses showed that serum beta-carotene concentration was predicted by fruit and vegetable intakes but was inversely associated with body mass, energy and alcohol intakes, and tobacco use. Serum vitamin C concentration was positively associated with fruit consumption but was negatively associated with age, body mass, and tobacco use. Serum beta-carotene and vitamin C concentrations are useful biomarkers of vegetable and fruit consumption in the French diet. However, other dietary and lifestyle factors also have a significant effect on circulating concentrations of these antioxidant micronutrients.
蔬菜和水果摄入量相对较高而脂肪摄入量相对较低与心脏病和多种癌症的发病率较低相关。蔬菜和水果摄入量的生物标志物在适用于不同年龄、体重、饮食以及不同脂肪摄入模式时最为有用。本研究在一个以社区为基础的法国成年人样本中，考察了两种生物标志物，即血清β-胡萝卜素和维生素C的浓度，作为人体测量、饮食和生活方式因素的函数。采用基于访谈的饮食史方法评估了居住在巴黎东南部马恩河谷地区的361名男性和476名年龄在18 - 94岁女性的饮食摄入量。血清β-胡萝卜素通过高效液相色谱法进行定量，维生素C采用自动方法进行测量。血清β-胡萝卜素和维生素C浓度与蔬菜和水果摄入量呈正相关，与能量、酒精和脂肪的摄入量呈负相关。多元回归分析表明，血清β-胡萝卜素浓度可由水果和蔬菜摄入量预测，但与体重、能量和酒精摄入量以及吸烟呈负相关。血清维生素C浓度与水果摄入量呈正相关，但与年龄、体重和吸烟呈负相关。血清β-胡萝卜素和维生素C浓度是法国饮食中蔬菜和水果摄入量的有用生物标志物。然而，其他饮食和生活方式因素也对这些抗氧化微量营养素的循环浓度有显著影响。
