蝶形酸和蝶形酮，由一种蝶形菌属物种产生的两种新型烟酰胺腺嘌呤二核苷酸（NADH）：泛醌氧化还原酶（复合体I）抑制剂。I. 生产、分离及生物学活性
Pterulinic acid and pterulone, two novel inhibitors of NADH:ubiquinone oxidoreductase (complex I) produced by a Pterula species. I. Production, isolation and biological activities.
作者信息
Engler M, Anke T, Sterner O, Brandt U
机构信息
LB Biotechnologie der Universität, Kaiserslautern, FRG.
出版信息
J Antibiot (Tokyo). 1997 Apr;50(4):325-9. doi: 10.7164/antibiotics.50.325.
PMID:9186558
Abstract
Pterulinic acid (1) and pterulone (2), two novel halogenated antibiotics, were isolated from fermentations of Pterula sp. 82168. Both compounds exhibited significant antifungal and weak or no cytotoxic activities. 1 and 2 are effective inhibitors of eucaryotic respiration. The target of the antibiotics resides within the mitochondrial NADH:ubiquinone oxidoreductase (complex I).
摘要
从盘菌属菌株82168的发酵产物中分离出两种新型卤代抗生素——蝶形酸（1）和蝶形酮（2）。这两种化合物均表现出显著的抗真菌活性，以及较弱的细胞毒性或无细胞毒性。1和2是真核生物呼吸的有效抑制剂。这些抗生素的作用靶点位于线粒体NADH：泛醌氧化还原酶（复合体I）内。
Zotero 插件