Lehmuskallio E, Hannuksela M, Halme H
Acta Med Scand. 1977;202(4):289-93. doi: 10.1111/j.0954-6820.1977.tb16829.x.
Neddle biopsies of the liver were performed in 121 cases of sarcoidosis. Granulomas compatible with sarcoidosis were seen in 24 percent of the cases. Liver function tests (serum alkaline phosphatase, serum aspartate aminotransferase, serum alanine aminotransferase, and bromsulphthalein clearance test) were performed on 325 patients with sarcoidosis and on 132 with non-sarcoid erythema nodosum (EN). Pathological findings were seen especially in patients with extensive EN, without any correlation with the disease responsible for the eruption. Hepatic granulomas were found more often in patients with sarcoid changes in lung parenchyma than in those with bilateral hilar adenitis only. There were no other definite correlations between hepatic granulomas and other clinical and laboratory findings. The incidence of pathological results in this study was clearly lower than, e.g., in the USA, thus reflecting the good prognosis of sarcoidosis in the Scandinavian countries.
对121例结节病患者进行了肝脏穿刺活检。24%的病例中可见符合结节病的肉芽肿。对325例结节病患者和132例非结节病性结节性红斑（EN）患者进行了肝功能检查（血清碱性磷酸酶、血清天冬氨酸氨基转移酶、血清丙氨酸氨基转移酶和磺溴酞钠清除试验）。病理结果尤其在广泛性EN患者中可见，与引起皮疹的疾病无任何相关性。肝肉芽肿在肺实质有结节病改变的患者中比仅双侧肺门淋巴结炎患者中更常见。肝肉芽肿与其他临床及实验室检查结果之间无其他明确相关性。本研究中病理结果的发生率明显低于例如美国，从而反映了斯堪的纳维亚国家结节病的良好预后。
