两种人类组织相容性抗原HLA - A2和HLA - B7的氨基酸序列比较：假定同种抗原位点的定位
Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites.
作者信息
Orr H T, Lopez de Castro J A, Parham P, Ploegh H L, Strominger J L
出版信息
Proc Natl Acad Sci U S A. 1979 Sep;76(9):4395-9. doi: 10.1073/pnas.76.9.4395.
Abstract
The complete amino acid sequence for papain-solubilized HLA-B7 heavy chain is compared with the partial sequences of HLA-A2 and H-2Kb heavy chains. Although these molecules are highly conserved (i.e., 80% homology in comparing HLA-B7 with HLA-A2; 72% and 74% homology in comparing H-2Kb with HLA-A2 and HLA-B7, respectively), two stretches of greater variability are observed. These clusters of variability are discussed in terms of their possible involvement in the alloantigenic determinant(s) characteristic of these highly polymorphic membrane antigens.
摘要
将木瓜蛋白酶可溶解的HLA - B7重链的完整氨基酸序列与HLA - A2和H - 2Kb重链的部分序列进行比较。尽管这些分子高度保守（即HLA - B7与HLA - A2相比有80%的同源性；H - 2Kb与HLA - A2和HLA - B7相比分别有72%和74%的同源性），但仍观察到两段变异性更高的区域。根据这些高变区域可能参与这些高度多态性膜抗原所特有的同种抗原决定簇的情况进行了讨论。
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