Snape W J, Carlson G M, Cohen S
Am J Dig Dis. 1977 Oct;22(10):881-7. doi: 10.1007/BF01076164.
Colonic myoelectric activity was determined using a mucosal clip electrode in normal human subjects, in the basal state and following the administration of prostigmin, pentagastrin, cholecystokinin, or secretin. Slow-wave activity was present 49 +/- 3.0% of the recording time and occurred at two frequencies, 6.5 +/- 0.1 cycles/min and 3.5 +/- 0.1 cycles/min, in the rectum. Spike potentials were infrequent in the basal state. Prostigmin, pentagastrin, or cholecystokinin did not affect the slow-wave activity or frequency, but these agents significantly increased the number of spike potentials (P less than 0.05). Secretin had no effect on myoelectric activity. The electrode system was tested in the cat and showed excellent correlation of the myoelectric activity between the mucosal clip electrode and a serosal electrode. These studies indicate: (1) a mucosal clip electrode provides an accurate method of recording colonic myoelectric activity when compared to a serosal electrode in the cat; (2) in man, slow-wave activity is present only intermittently and exists at two frequencies, approximately 6 cycles/min and 3 cycles/min; (3) gastrointestinal hormones and prostigmin increase spike potential discharge without altering slow-wave activity or frequency.
在正常人体受试者中，使用黏膜夹电极在基础状态下以及给予新斯的明、五肽胃泌素、胆囊收缩素或促胰液素后测定结肠肌电活动。慢波活动在记录时间的49±3.0%出现，在直肠以6.5±0.1次/分钟和3.5±0.1次/分钟两个频率发生。在基础状态下动作电位很少见。新斯的明、五肽胃泌素或胆囊收缩素不影响慢波活动或频率，但这些药物显著增加动作电位数量（P<0.05）。促胰液素对肌电活动无影响。该电极系统在猫身上进行了测试，结果显示黏膜夹电极和浆膜电极之间的肌电活动具有良好的相关性。这些研究表明：（1）与猫的浆膜电极相比，黏膜夹电极提供了一种记录结肠肌电活动的准确方法；（2）在人类中，慢波活动仅间歇性出现，且以大约6次/分钟和3次/分钟两个频率存在；（3）胃肠激素和新斯的明增加动作电位发放，而不改变慢波活动或频率。
