Vanduffel W, Payne B R, Lomber S G, Orban G A
Laboratorium voor Neuro- en Psychofysiologie, Faculteit Geneeskunde, Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.
Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7617-20. doi: 10.1073/pnas.94.14.7617.
Cerebral networks are complex sets of connections that resemble a ladder-like web of multiple parallel feedforward, lateral, and feedback connections. This static anatomical description has been pivotal in guiding our understanding of signal processing within cerebral networks. However, measures on both magnitude and functional significance of connections are extremely limited. Here, we compare the anatomically defined strengths of a set of cerebral pathways emerging from the visual middle suprasylvian (MS) cortex of the cat with measures of the functional impact the same region has over distant sites. These functional measures were obtained by analyzing the local and distant effects of MS cooling deactivation on deoxyglucose uptake. Relative to major efferent projections from MS cortex that have a strong influence, projections to early visual processing stages have weaker functional influences than predicted from the anatomy. For higher processing stages, the converse holds: projections from MS cortex have stronger functional influence than predicted from the anatomy. We conclude that these and future functional measures, obtained using the same combination of techniques, will furnish fundamental, new information that complements and extends current models of static cerebral networks, and lead to more realistic models of cerebral network function and component interactions.
脑网络是复杂的连接集合，类似于由多个平行的前馈、侧向和反馈连接构成的阶梯状网络。这种静态的解剖学描述对于引导我们理解脑网络内的信号处理起到了关键作用。然而，关于连接的强度和功能重要性的测量极其有限。在这里，我们将猫视觉中颞上回（MS）皮质发出的一组脑通路的解剖学定义强度，与该区域对远处位点的功能影响测量进行比较。这些功能测量是通过分析MS冷却失活对脱氧葡萄糖摄取的局部和远处影响而获得的。相对于具有强烈影响的MS皮质主要传出投射，投射到早期视觉处理阶段的功能影响比根据解剖学预测的要弱。对于更高的处理阶段，情况则相反：来自MS皮质的投射具有比根据解剖学预测更强的功能影响。我们得出结论，这些以及未来使用相同技术组合获得的功能测量，将提供补充和扩展当前静态脑网络模型的基础新信息，并导致更现实的脑网络功能和组件相互作用模型。
