七氟烷与氟烷用于小儿门诊麻醉的比较：台湾地区的经验

Comparison of sevoflurane with halothane in pediatric ambulatory anesthesia: an experience in Taiwan.

作者信息

Chong Z K, Jawan B, Poon Y Y, Lee J H

机构信息

Department of Anesthesiology, Chang Gung Medical College, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, R.O.C.

出版信息

Acta Anaesthesiol Sin. 1997 Mar;35(1):21-4.

PMID:9212477

Abstract

BACKGROUND

Sevoflurane, with blood/gas partition coefficient of 0.69 and MAC of 1.76 is a fast acting, potent inhalation anesthetic. Its suitability and safety for pediatric ambulatory anesthesia were assessed and compared with that of halothane.

METHODS

Thirty two unpremedicated pediatric patients undergoing elective herniorrhaphy on day-surgery basis were randomly allocated to 2 groups of equal number to receive either sevoflurane or halothane anesthesia. Employing mask technique, anesthesia was induced with 60% nitrous oxide and 3 MAC of either sevoflurane or halothane in oxygen. Anesthesia was maintained respectively with 1-1.5 MAC of sevoflurane or halothane. The induction time, emergence time and untoward effects during anesthesia were analyzed and compared.

RESULTS

It was shown that both the induction time and emergence time were significantly shorter in patients receiving sevoflurane. None had major complications.

CONCLUSIONS

The results strongly suggest that sevoflurane is preferable to halothane for pediatric ambulatory anesthesia.

摘要

背景

七氟醚的血/气分配系数为0.69，最低肺泡有效浓度为1.76，是一种起效迅速、强效的吸入麻醉剂。对其用于小儿门诊麻醉的适用性和安全性进行了评估，并与氟烷进行了比较。

方法

32例未使用术前药、在日间手术基础上接受择期疝修补术的小儿患者被随机分为两组，每组人数相等，分别接受七氟醚或氟烷麻醉。采用面罩技术，用60%氧化亚氮和3倍最低肺泡有效浓度的七氟醚或氟烷与氧气混合进行麻醉诱导。分别用1-1.5倍最低肺泡有效浓度的七氟醚或氟烷维持麻醉。对诱导时间、苏醒时间及麻醉期间的不良反应进行分析和比较。