Rabkin S W, Chen Y, Leiter L, Liu L, Reeder B A
Department of Medicine, University of British Columbia, Vancouver.
CMAJ. 1997 Jul 1;157 Suppl 1:S26-31.
To examine the association of obesity, as reflected by body mass index, with other cardiovascular risk factors specifically blood pressure, smoking, physical inactivity, plasma lipid levels and diabetes mellitus.
Population-based, cross-sectional surveys.
Ten Canadian provinces between 1986 and 1992.
A probability sample of 29,855 men and women aged 18 to 74 years was selected from the health insurance registration files of each province and invited to participate. Anthropometry was performed on 19,841 (66%) of these adults.
Body mass index (BMI, kg/m2), systolic and diastolic blood pressure, smoking status, level of leisure-time physical activity, self-reported diabetes, levels of plasma total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL) and triglycerides (TRIG).
The prevalence of high blood pressure increased with increasing BMI. The gradient of increase was steepest for younger (18-34 years) men and women compared with older (55-74 years) groups. The prevalence of physical inactivity in women tended to increase with increasing BMI except in the lowest BMI category. The J-shaped relationship, although weaker, was also seen in men. The prevalence of self-reported diabetes mellitus was greater with higher BMI categories at all ages and for both sexes except for the youngest group of men. The prevalence of dyslipidemia was related to BMI, as LDL and TRIG levels were higher and HDL levels lower in those with higher BMI. BMI was strongly related to blood pressure, diabetes mellitus and lipid abnormalities.
These data suggest a central role for obesity in cardiovascular risk and the potential importance of intervention strategies aimed at reducing population obesity in the management of other cardiovascular risk factors.
研究以体重指数反映的肥胖与其他心血管危险因素，特别是血压、吸烟、身体活动不足、血脂水平和糖尿病之间的关联。
基于人群的横断面调查。
1986年至1992年期间的加拿大十个省份。
从每个省份的健康保险登记档案中选取了29855名年龄在18至74岁之间的男性和女性作为概率样本，并邀请他们参与。对其中19841名（66%）成年人进行了人体测量。
体重指数（BMI，kg/m²）、收缩压和舒张压、吸烟状况、休闲时间身体活动水平、自我报告的糖尿病、血浆总胆固醇、高密度脂蛋白胆固醇（HDL）、低密度脂蛋白胆固醇（LDL）和甘油三酯（TRIG）水平。
高血压患病率随BMI升高而增加。与年龄较大（55 - 74岁）的人群相比，年龄较小（18 - 34岁）的男性和女性患病率上升梯度最陡。除BMI最低类别外，女性身体活动不足的患病率往往随BMI升高而增加。男性中也观察到J形关系，尽管较弱。在所有年龄段和男女两性中，除最年轻的男性组外，自我报告的糖尿病患病率在BMI较高类别中更高。血脂异常患病率与BMI相关，BMI较高者的LDL和TRIG水平较高，HDL水平较低。BMI与血压、糖尿病和血脂异常密切相关。
这些数据表明肥胖在心血管风险中起核心作用，以及旨在降低人群肥胖的干预策略在管理其他心血管危险因素方面的潜在重要性。
