Liedtke W, Malessa R, Faustmann P M, Eis-Hübinger A M
Department of Neurology of Essen University Hospital, Germany.
J Neurovirol. 1995 Sep;1(3-4):253-8. doi: 10.3109/13550289509114021.
A role for human herpesvirus 6 (HHV6) in the neurological complications associated with infection by human immunodeficiency virus (neuro-AIDS) and during multiple sclerosis (MS) is not known. For the present study, an improved PCR and immunofluorescence serology method were applied to sera and cerebrospinal fluid (CSF) from 27 neuro-AIDS, 36 MS and 24 non-inflammatory control patients. HHV6 DNA was present in 30-40% of the cellular CSF from all groups. In the acellular CSF, HHV6 could be detected in four of 36 MS, 2 of 27 neuro-AIDS and none of the control patients. HHV6 IgG was present in one of 27 neuro-AIDS, and one of 36 MS patients. HHV6 IgG was present in all patients. There was no correlation between clinical features and HHV6 PCR findings or HHV6 antibodies. The significance of the present documentation of HHV6 DNA in the acellular CSF from a minority of MS and neuro-AIDS patients remains to be determined.
人类疱疹病毒6型（HHV6）在与人类免疫缺陷病毒感染相关的神经并发症（神经艾滋病）以及多发性硬化症（MS）期间所起的作用尚不清楚。在本研究中，一种改进的聚合酶链反应（PCR）和免疫荧光血清学方法被应用于27例神经艾滋病患者、36例MS患者和24例非炎症对照患者的血清和脑脊液（CSF）。所有组中30%-40%的细胞性脑脊液中存在HHV6 DNA。在无细胞脑脊液中，36例MS患者中有4例、27例神经艾滋病患者中有2例检测到HHV6，而对照患者均未检测到。27例神经艾滋病患者中有1例、36例MS患者中有1例存在HHV6 IgG。所有患者中均存在HHV6 IgG。临床特征与HHV6 PCR结果或HHV6抗体之间无相关性。少数MS和神经艾滋病患者无细胞脑脊液中HHV6 DNA的现有记录的意义仍有待确定。
