Fisher Naomi Deirdre Lakshmi, Orav Endel John, Chang Grace
a Department of Medicine , Harvard Medical School , Boston , MA , USA.
b Department of Psychiatry , Harvard Medical School , Boston , MA , USA.
Am J Drug Alcohol Abuse. 2018;44(2):200-205. doi: 10.1080/00952990.2017.1355921. Epub 2017 Aug 14.
Problem drinking carries significant health burdens, including an increased risk of hypertension. The effect of chronic alcohol intake on blood pressure (BP) in women is understudied and poorly understood.
We sought to examine the relationships between drinking habits and BP in hypertensive women.
We analyzed drinking habits in 113 women followed in the Brigham and Women's Hospital Hypertension Clinic for at least one year.
Among these women with well-controlled hypertension, baseline diastolic BP was significantly lower in moderate drinkers compared with women who rarely or never drank. Changes in both systolic and diastolic BP over 12 months showed a significant negative association with changes in percent drinking days. In contrast, there was a trend toward higher baseline systolic BP among those women who consumed more drinks per drinking day.
Among these women with controlled hypertension, our data failed to demonstrate an association between drinking beyond recommended limits and higher disease burden. These findings parallel the widely reported difference between drinking frequency, associated with a host of positive health outcomes, and drinking intensity, associated with negative outcomes. Novel to this report is an observed reduction in blood pressure over the one-year follow-up period accompanying an increased drinking frequency in treated hypertensive women. Cautions include the suggestion that a greater number of drinks per drinking day was associated with higher baseline pressure. These data imply that drinking within sensible limits has no negative impact on chronic hypertension. In fact, for women with well-controlled hypertension, such a habit may impart benefit.
问题饮酒会带来重大的健康负担,包括高血压风险增加。慢性酒精摄入对女性血压(BP)的影响研究不足且了解甚少。
我们试图研究高血压女性饮酒习惯与血压之间的关系。
我们分析了在布莱根妇女医院高血压诊所随访至少一年的113名女性的饮酒习惯。
在这些高血压得到良好控制的女性中,中度饮酒者的基线舒张压显著低于很少饮酒或从不饮酒的女性。12个月内收缩压和舒张压的变化与饮酒天数百分比的变化呈显著负相关。相比之下,每天饮酒量较多的女性基线收缩压有升高趋势。
在这些高血压得到控制的女性中,我们的数据未能证明饮酒超过推荐限量与更高的疾病负担之间存在关联。这些发现与广泛报道的饮酒频率(与一系列积极健康结果相关)和饮酒强度(与消极结果相关)之间的差异一致。本报告的新颖之处在于观察到在接受治疗的高血压女性中,随着饮酒频率增加,在一年随访期内血压有所下降。需要注意的是,每天饮酒量较多与更高的基线血压相关。这些数据表明,适度饮酒对慢性高血压没有负面影响。事实上,对于高血压得到良好控制的女性,这样的习惯可能有益。