牛轮状病毒993/83显示出禽VP7蛋白的第三种亚型。
Bovine rotavirus 993/83 shows a third subtype of avian VP7 protein.
作者信息
Rohwedder A, Hotop H, Minamoto N, Ito H, Nakagomi O, Brüssow H
机构信息
Department of Medical Microbiology and Virology, Ruhr-University Bochum, Germany.
出版信息
Virus Genes. 1997;14(2):147-51. doi: 10.1023/a:1007921418679.
VP7 genes of rotavirus (RV) 993/83 isolated from a German calf with diarrhea and of RV PO-13 isolated from a Japanese pigeon were sequenced. Alignment of the deduced VP7 amino acid sequence showed 98.8% sequence identity, while only 70% and 84% identity was seen with VP7 from chicken RV Ch-2 and turkey RV Ty-1, respectively. Over the antigenic regions A, B, and C mammalian RV 993/83 showed more aa identity with mammalian G3 RVs than with chicken RV Ch-2, which could explain the strong one-way cross-neutralization observed between RV 993/83 and G3 RVs. Despite marked VP7 sequence diversity avian RVs could not be differentiated into distinct G types.
对从一头患腹泻的德国小牛分离出的轮状病毒（RV）993/83以及从一只日本鸽子分离出的RV PO - 13的VP7基因进行了测序。推导的VP7氨基酸序列比对显示序列同一性为98.8%，而与鸡RV Ch - 2和火鸡RV Ty - 1的VP7的同一性分别仅为70%和84%。在抗原区域A、B和C中，哺乳动物RV 993/83与哺乳动物G3 RVs的氨基酸同一性高于与鸡RV Ch - 2的，这可以解释在RV 993/83和G3 RVs之间观察到的强烈单向交叉中和现象。尽管VP7序列存在显著差异，但禽RVs无法被区分为不同的G型。
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