Bayrle W
Geburtshilfe Frauenheilkd. 1977 Oct;37(10):864-8.
In order to obtain a resonable approach to the rate of false negative findings in gynecologic cytology, all cases available to the authors for analysis with cervical carcinoma, carcinoma in situ and dysplasia during 1971 to 1973 were examined for any previous history of negative cytologic findings during the years preceding the detection of these pathologic conditions. It was found that negative results had been obtained in 11% of the patients suffering from cervical carcinoma, whereas the corresponding percentage figure was 18% negative results in carcinoma in situ patients. However, in about half of the cases, repetition of the smear had been recommended. Among the possible causes of false negative cytologic findings, the laboratory error (screening and evaluation) is the only one which can be accurately determined; in the present analysis, one-third of the false findings were found to be due to laboratory error. It is probable that the majority of the other false negative cytologic findings are mainly due to errors in sampling. As a matter of fact, rapidly growing carcinomas and carcinomas in situ are probably rare.
为了找到一种合理的方法来处理妇科细胞学检查中的假阴性结果，作者对1971年至1973年间所有可用于分析的宫颈癌、原位癌和发育异常病例进行了检查，以了解在这些病理状况被检测出之前的数年里，患者是否有过细胞学检查结果为阴性的病史。结果发现，患宫颈癌的患者中有11%曾有过阴性结果，而原位癌患者中相应的阴性结果比例为18%。然而，在大约一半的病例中，曾建议重复涂片检查。在假阴性细胞学检查结果的可能原因中，实验室误差（筛查和评估）是唯一能够准确确定的原因；在本分析中，发现三分之一的假结果是由实验室误差导致的。其他大多数假阴性细胞学检查结果很可能主要是由于取样误差。事实上，快速生长的癌和原位癌可能很少见。
