Laatikainen L, Larinkari J
Invest Ophthalmol Vis Sci. 1977 Dec;16(12):1154-7.
The mean diameter of the capillary-free zone of the fovea was measured on fluorescein angiograms of 167 eyes of 158 patients. In all eyes examined, a clear-cut capillary-free area was found, although in a few cases one or two capillaries crossing the avascular zone were seen. There was a considerable individual variation in each age group. The mean diameter of the capillary-free zone was 0.53 mm. in patients between 10 and 39 years of age and 0.61 mm. after the age of 40. This difference is statistically highly significant (p less than 0.001), indicating some occlusion or atrophy of the macular capillaries by age, but no further increase in the mean diameter of the avascular zone was observed during the fifth decade or later. Findings in the two youngest patients, 12 and 22 months of age, were roughly comparable with those observed in adults.
对158例患者的167只眼进行荧光素血管造影，测量了黄斑中心凹无毛细血管区的平均直径。在所有检查的眼中，均发现了明确的无毛细血管区，尽管在少数情况下可见一两条毛细血管穿过无血管区。每个年龄组都存在相当大的个体差异。10至39岁患者的无毛细血管区平均直径为0.53毫米，40岁以后为0.61毫米。这种差异在统计学上具有高度显著性（p小于0.001），表明随着年龄增长，黄斑毛细血管存在一定程度的闭塞或萎缩，但在第五个十年及以后未观察到无血管区平均直径的进一步增加。两名最年轻患者（年龄分别为12个月和22个月）的检查结果与成年人的大致相当。
