无浆霉素的结构

Structure of aplasmomycin.

作者信息

Nakamura H, Iitaka Y, Kitahara T, Okazaki T, Okami Y

出版信息

J Antibiot (Tokyo). 1977 Sep;30(9):714-9. doi: 10.7164/antibiotics.30.714.

DOI:10.7164/antibiotics.30.714

Abstract

A new antibiotic, aplasmomycin, was isolated from a broth cultivated with a marine isolate of actinomycete, and inhibits Gram-positive bacteria in vitro and Plasmodium berghei in vivo. It is a natural ionophore and the structure of the Ag-salt was solved by an X-ray crystallographic analysis. It has symmetric structure having boron in the centre of the molecule.

摘要

一种新的抗生素——无浆霉素，是从用海洋放线菌分离株培养的肉汤中分离出来的，它在体外能抑制革兰氏阳性菌，在体内能抑制伯氏疟原虫。它是一种天然离子载体，通过X射线晶体学分析确定了其银盐的结构。它具有对称结构，分子中心含有硼。