咔唑霉素G和H，含喹啉部分的新型咔唑霉素同系物。

Carbazomycins G and H, novel carbazomycin-congeners containing a quinol moiety.

作者信息

Kaneda M, Naid T, Kitahara T, Nakamura S, Hirata T, Suga T

机构信息

Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.

出版信息

J Antibiot (Tokyo). 1988 May;41(5):602-8. doi: 10.7164/antibiotics.41.602.

DOI:10.7164/antibiotics.41.602

PMID:3384748

Abstract

Carbazomycins G (I) and H (II), new congeners of the carbazomycin complex, have been isolated from the culture broth of Streptoverticillium ehimense. They have proved to contain a unique quinol moiety in the molecule. Their structures have been elucidated by mass and NMR spectrometries and X-ray crystallographic analysis. Carbazomycin G showed moderate antifungal activity against Trichophyton species.

摘要

咔唑霉素G（I）和H（II）是咔唑霉素复合物的新同系物，已从埃希链霉菌的发酵液中分离得到。它们被证明在分子中含有独特的喹啉部分。通过质谱、核磁共振光谱和X射线晶体学分析阐明了它们的结构。咔唑霉素G对毛癣菌属显示出中等抗真菌活性。