Suzuki K, Mizokami M, Cao K, Wu X S, Wu R R, Hata A, Sasaki M, Fang Z X, Zhang L Y, Lau J Y, Iino S
Second Department of Medicine, Nagoya City University Medical School, Japan.
Eur J Epidemiol. 1997 Jul;13(5):511-5. doi: 10.1023/a:1007320118967.
There is little information on the prevalence of hepatitis C virus (HCV) infection in China. The prevalence of HCV infection was determined in 998 subjects (398 with liver disease and 600 without) in the city of Nanjing in southern China. Subjects were tested for anti-HCV antibodies by a second generation assay. We also determined serological HCV genotypes and HCV RNA sequences. Among the 600 subjects without liver disease, 3 (0.5%) were seroreactive for anti-HCV. All were less than 12 years of age and had a history of transfusion. Of the 398 liver disease patients, 20 (5.0%) were seroreactive for anti-HCV. Of 16 patients in whom serological HCV genotype was determined, 10 (62.5%) were infected with HCV type 1, 5 (31.3%) with type 2 and 1 (6.3%) undetermined. HCV genomes sequenced from 2 patients belonged to genotype 2 and were closely related to strains in Beijing and Japan by molecular evolutionary analysis. These results suggest that HCV infection is rare and not a major cause of liver disease in southern China.
关于中国丙型肝炎病毒（HCV）感染的流行情况，现有信息较少。在中国南方的南京市，对998名受试者（398名患有肝脏疾病，600名未患肝脏疾病）进行了HCV感染流行情况的测定。通过第二代检测方法对受试者进行抗HCV抗体检测。我们还测定了血清学HCV基因型和HCV RNA序列。在600名未患肝脏疾病的受试者中，3名（0.5%）抗HCV血清反应呈阳性。所有这些受试者年龄均小于12岁，且有输血史。在398名肝脏疾病患者中，20名（5.0%）抗HCV血清反应呈阳性。在16名已确定血清学HCV基因型的患者中，10名（62.5%）感染了1型HCV，5名（31.3%）感染了2型HCV，1名（6.3%）未确定。通过分子进化分析，从2名患者中测序得到的HCV基因组属于2型，并且与北京和日本的毒株密切相关。这些结果表明，在中国南方，HCV感染较为罕见，并非肝脏疾病的主要病因。
