Kupfer D M, Reece C A, Clifton S W, Roe B A, Prade R A
Department of Biochemistry and Chemistry, University of Oklahoma, Norman 73019-0390, USA.
Fungal Genet Biol. 1997 Jun;21(3):364-72. doi: 10.1006/fgbi.1997.0982.
Fungi comprise a large monophyletic group of uni- and multicellular eukaryotic organisms in which many species are of economic or medical importance. Fungal genomes are variable in size (13-42 Mb), and multicellular species support true spatial and temporal cell-type-specific regulation of gene expression. In a 38.8-kb Aspergillus nidulans contiguous genomic DNA region, a transposable element and 12 potential genes were identified, 7 similar to genes in other organisms. This observation is consistent with the prediction that multicellular ascomycetous fungi harbor 8000-9000 genes in a 36-Mb average genome. Thus, the genomic DNA sequence of filamentous fungi will provide substantial amounts of genetic and functional information that is not available in yeast, for the human and other metazoan minimal gene complement.
真菌是一大类单细胞和多细胞真核生物的单系群，其中许多物种具有经济或医学重要性。真菌基因组大小各异（13 - 42兆碱基），多细胞物种支持基因表达的真正时空细胞类型特异性调控。在一个38.8千碱基的构巢曲霉连续基因组DNA区域中，鉴定出一个转座元件和12个潜在基因，其中7个与其他生物中的基因相似。这一观察结果与以下预测一致：多细胞子囊菌在平均36兆碱基的基因组中含有8000 - 9000个基因。因此，丝状真菌的基因组DNA序列将为人类和其他后生动物的最小基因互补提供大量酵母中所没有的遗传和功能信息。
