Appenrodt E, Bojanowska E, Janus J, Stempniak B, Guzek J W, Schwarzberg H
Department of Neurophysiology, Otto-von-Guericke University, Magdeburg, Germany.
Pharmacol Biochem Behav. 1997 Oct;58(2):415-9. doi: 10.1016/s0091-3057(97)00242-6.
Although previous reports have shown that methylphenidate (MPH), in addition to its known behavioral effect, can influence the hypothalamo-pituitary-adrenal axis by increasing the plasma ACTH, the pineal gland seems to be involved in neuroendocrinological processes too, e.g., in hypothalamic synthesis and release of oxytocin (OXY) and vasopressin (AVP). Therefore, a study was performed to measure the OXY and AVP content of the hypothalamus, neurohypophysis, and plasma after application of MPH in the morning and evening in pinealectomized (PE) as well as sham-operated control (SO) rats. Pinealectomy influenced both the daily pattern (reversed in the neurohypophysis) and the levels of OXY and AVP. Starting from this different situation, application of MPH produced diverse effects. Hypothalamus: PE, increase in both hormones in the morning and evening; SO, decrease in morning OXY level. Neurohypophysis: PE, increase in morning OXY level; SO, decrease in both hormones even though in the morning only. Plasma: PE, decrease in morning OXY concentration; SO, increase in both hormones in the morning and decrease in the evening. The present results indicate that MPH application influences the hypothalamo-neurohypophysial system. Furthermore, the hypothesis has been supported that this influence may be dependent on the circadian activity of the pineal gland as well.
尽管先前的报告显示，哌醋甲酯（MPH）除了具有已知的行为效应外，还可通过增加血浆促肾上腺皮质激素（ACTH）来影响下丘脑-垂体-肾上腺轴，但松果体似乎也参与神经内分泌过程，例如下丘脑合成和释放催产素（OXY）和抗利尿激素（AVP）。因此，本研究对松果体切除（PE）大鼠和假手术对照（SO）大鼠在早晚应用MPH后，测量其下丘脑、神经垂体和血浆中的OXY和AVP含量。松果体切除影响了OXY和AVP的每日变化模式（神经垂体中模式逆转）及其水平。基于这种不同的情况，应用MPH产生了不同的效果。下丘脑：PE组，早晚两种激素均增加；SO组，早晨OXY水平降低。神经垂体：PE组，早晨OXY水平增加；SO组，两种激素均降低，不过仅在早晨降低。血浆：PE组，早晨OXY浓度降低；SO组，两种激素在早晨增加而在晚上降低。目前的结果表明，应用MPH会影响下丘脑-神经垂体系统。此外，该影响可能也取决于松果体的昼夜活动这一假设得到了支持。
