Riesenfeld C, Everett M, Piddock L J, Hall B G
Department of Biology, University of Rochester, New York 14627, USA.
Antimicrob Agents Chemother. 1997 Sep;41(9):2059-60. doi: 10.1128/AAC.41.9.2059.
Mutation to ciprofloxacin resistance continually occurred in nondividing Escherichia coli cells during a 7-day exposure to ciprofloxacin in agar, while no accumulation of rifampin resistance mutations was detected in those cells. We propose that the resistance mutations result from adaptive mutations, which preferentially produce phenotypes that promote growth in nondividing cells.
在琼脂中对环丙沙星进行7天暴露处理期间，非分裂的大肠杆菌细胞持续发生对环丙沙星的耐药性突变，而在这些细胞中未检测到利福平耐药性突变的积累。我们提出，耐药性突变是由适应性突变产生的，这些突变优先产生促进非分裂细胞生长的表型。
