囊性纤维化患者分离出的丝状真菌对两性霉素B、伊曲康唑和咪康唑的体外敏感性
In vitro susceptibilities to amphotericin B, itraconazole, and miconazole of filamentous fungi isolated from patients with cystic fibrosis.
作者信息
Hennequin C, Benailly N, Silly C, Sorin M, Scheinmann P, Lenoir G, Gaillard J L, Berche P
机构信息
Laboratoire de Parasitologie, Service de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France.
出版信息
Antimicrob Agents Chemother. 1997 Sep;41(9):2064-6. doi: 10.1128/AAC.41.9.2064.
Abstract
The antimicrobial activities of amphotericin B, itraconazole, and miconazole against 101 filamentous fungi from patients with cystic fibrosis were tested by a reproducible microdilution method. Itraconazole was very active against Aspergillus species and Scedosporium species (MIC at which 90% of the isolates were inhibited [MIC90], 0.06 to 0.5 mg/liter), whereas amphotericin B was less effective (MIC90, 0.5 to 8 mg/liter).
摘要
采用可重复的微量稀释法，对两性霉素B、伊曲康唑和咪康唑针对101株来自囊性纤维化患者的丝状真菌的抗菌活性进行了测试。伊曲康唑对曲霉菌属和赛多孢属非常有效（90%分离株被抑制时的最低抑菌浓度[MIC90]，0.06至0.5毫克/升），而两性霉素B的效果较差（MIC90，0.5至8毫克/升）。
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