白细胞介素-12的缺失加剧了SCID小鼠的莱姆关节炎。
Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice.
作者信息
Anguita J, Samanta S, Barthold S W, Fikrig E
机构信息
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA.
出版信息
Infect Immun. 1997 Oct;65(10):4334-6. doi: 10.1128/iai.65.10.4334-4336.1997.
Abstract
The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthritis. These results contrasted with the reduction of Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T-cell responses leads to an exacerbation of joint inflammation.
摘要
给感染伯氏疏螺旋体的C3H/HeN-scid小鼠注射白细胞介素-12（IL-12）抗体，会加重急性莱姆关节炎的严重程度。这些结果与免疫功能正常的动物中IL-12抗体减轻莱姆关节炎的情况形成对比。这些数据表明，在缺乏B细胞和T细胞反应的情况下，SCID小鼠固有免疫的下调会导致关节炎症加剧。
相似文献
1
Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice.白细胞介素-12的缺失加剧了SCID小鼠的莱姆关节炎。
Infect Immun. 1997 Oct;65(10):4334-6. doi: 10.1128/iai.65.10.4334-4336.1997.
2
Significant differences between the Borrelia-infection and Borrelia-vaccination and -infection models of Lyme arthritis in C3H/HeN mice.C3H/HeN小鼠莱姆关节炎的伯氏疏螺旋体感染模型与伯氏疏螺旋体疫苗接种及感染模型之间的显著差异。
FEMS Immunol Med Microbiol. 2010 Oct;60(1):78-89. doi: 10.1111/j.1574-695X.2010.00721.x.
3
The DBA/1 strain is a novel mouse model for experimental Borrelia burgdorferi infection.DBA/1品系是一种用于实验性伯氏疏螺旋体感染的新型小鼠模型。
Clin Vaccine Immunol. 2012 Oct;19(10):1567-73. doi: 10.1128/CVI.00251-12. Epub 2012 Aug 1.
4
Mercury exposure as a model for deviation of cytokine responses in experimental Lyme arthritis: HgCl2 treatment decreases T helper cell type 1-like responses and arthritis severity but delays eradication of Borrelia burgdorferi in C3H/HeN mice.汞暴露作为实验性莱姆关节炎中细胞因子反应偏差的模型：HgCl₂ 处理可降低 1 型辅助性 T 细胞样反应和关节炎严重程度，但会延迟 C3H/HeN 小鼠中伯氏疏螺旋体的清除。
Clin Exp Immunol. 2007 Oct;150(1):189-97. doi: 10.1111/j.1365-2249.2007.03474.x. Epub 2007 Aug 2.
5
Relative contributions of innate and acquired host responses to bacterial control and arthritis development in Lyme disease.先天和后天宿主反应对莱姆病细菌控制及关节炎发展的相对贡献。
Infect Immun. 2005 Jan;73(1):657-60. doi: 10.1128/IAI.73.1.657-660.2005.
6
Lyme borreliosis in genetically resistant and susceptible mice with severe combined immunodeficiency.重度联合免疫缺陷的基因抗性和易感性小鼠中的莱姆病螺旋体病
Am J Trop Med Hyg. 1992 Nov;47(5):605-13. doi: 10.4269/ajtmh.1992.47.605.
7
Arthritis severity and spirochete burden are determined by serotype in the Borrelia turicatae-mouse model of Lyme disease.在莱姆病的杜氏疏螺旋体-小鼠模型中，关节炎严重程度和螺旋体负荷由血清型决定。
Infect Immun. 1997 Jan;65(1):285-92. doi: 10.1128/iai.65.1.285-292.1997.
8
Infection of Interleukin 17 Receptor A-Deficient C3H Mice with Borrelia burgdorferi Does Not Affect Their Development of Lyme Arthritis and Carditis.用伯氏疏螺旋体感染白细胞介素17受体A缺陷的C3H小鼠，并不影响它们莱姆关节炎和心肌炎的发展。
Infect Immun. 2015 Jul;83(7):2882-8. doi: 10.1128/IAI.00533-15. Epub 2015 May 4.
9
Effect of anti-interleukin 12 treatment on murine lyme borreliosis.抗白细胞介素12治疗对小鼠莱姆病的影响。
J Clin Invest. 1996 Feb 15;97(4):1028-34. doi: 10.1172/JCI118494.
10
Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response.伯氏疏螺旋体，一种细胞外病原体，在诱导炎性细胞因子反应方面避开骨桥蛋白。
J Leukoc Biol. 2005 May;77(5):710-8. doi: 10.1189/jlb.0604356. Epub 2005 Feb 4.
引用本文的文献
1
CD4 T cell responses in persistent Borrelia burgdorferi infection.持续性伯氏疏螺旋体感染中的 CD4 T 细胞应答。
Curr Opin Immunol. 2022 Aug;77:102187. doi: 10.1016/j.coi.2022.102187. Epub 2022 May 9.
2
Lyme arthritis: current concepts and a change in paradigm.莱姆关节炎：当前概念与范式转变
Clin Vaccine Immunol. 2008 Jan;15(1):21-34. doi: 10.1128/CVI.00330-07. Epub 2007 Nov 14.
3
Innate immune responses in Lyme borreliosis: enhanced tumour necrosis factor-alpha and interleukin-12 in asymptomatic individuals in response to live spirochetes.莱姆病中的固有免疫反应：无症状个体对活螺旋体产生的肿瘤坏死因子-α和白细胞介素-12增强
Clin Exp Immunol. 2005 Jul;141(1):89-98. doi: 10.1111/j.1365-2249.2005.02820.x.
4
Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis.环氧化酶2的活性调节小鼠莱姆关节炎的严重程度。
FEMS Immunol Med Microbiol. 2002 Nov 15;34(3):187-91. doi: 10.1111/j.1574-695X.2002.tb00623.x.
5
Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi.骨桥蛋白在小鼠莱姆关节炎及宿主抵御伯氏疏螺旋体中的作用
Infect Immun. 2002 Mar;70(3):1372-81. doi: 10.1128/IAI.70.3.1372-1381.2002.
6
Immunohistochemical analysis of Lyme disease in the skin of naive and infection-immune rabbits following challenge.对初次接触和感染免疫的兔子在受到攻击后皮肤中莱姆病的免疫组织化学分析。
Infect Immun. 2001 Jun;69(6):4094-102. doi: 10.1128/IAI.69.6.4094-4102.2001.
7
Gamma interferon is not required for arthritis resistance in the murine Lyme disease model.在小鼠莱姆病模型中，抗关节炎不需要γ干扰素。
Infect Immun. 2001 Jun;69(6):3737-43. doi: 10.1128/IAI.69.6.3737-3743.2001.
8
Interleukin-4 (IL-4) and IL-13 signaling pathways do not regulate Borrelia burgdorferi-induced arthritis in mice: IgG1 is not required for host control of tissue spirochetes.白细胞介素-4（IL-4）和IL-13信号通路不调节小鼠中伯氏疏螺旋体诱导的关节炎：IgG1对于宿主控制组织螺旋体不是必需的。
Infect Immun. 2000 Oct;68(10):5603-9. doi: 10.1128/IAI.68.10.5603-5609.2000.
9
Dual role of interleukin-10 in murine Lyme disease: regulation of arthritis severity and host defense.白细胞介素-10在小鼠莱姆病中的双重作用：关节炎严重程度的调节和宿主防御。
Infect Immun. 1999 Oct;67(10):5142-50. doi: 10.1128/IAI.67.10.5142-5150.1999.
10
Genetic control of experimental lyme arthritis in the absence of specific immunity.在缺乏特异性免疫的情况下实验性莱姆关节炎的遗传控制
Infect Immun. 1999 Apr;67(4):1967-73. doi: 10.1128/IAI.67.4.1967-1973.1999.
本文引用的文献
1
Immunity to Lyme disease: protection, pathology and persistence.莱姆病免疫：保护、病理学与持续性
Curr Opin Immunol. 1996 Aug;8(4):503-9. doi: 10.1016/s0952-7915(96)80038-0.
2
CD40 ligand is required for protective cell-mediated immunity to Leishmania major.CD40配体对于针对硕大利什曼原虫的保护性细胞介导免疫是必需的。
Immunity. 1996 Mar;4(3):283-9. doi: 10.1016/s1074-7613(00)80436-7.
3
Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity.CD40在细胞介导免疫的两个不同阶段对硕大利什曼原虫感染的保护作用。
Immunity. 1996 Mar;4(3):275-81. doi: 10.1016/s1074-7613(00)80435-5.
4
Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection.CD40-CD40配体相互作用的破坏导致对亚马逊利什曼原虫感染的易感性增强。
Immunity. 1996 Mar;4(3):263-73. doi: 10.1016/s1074-7613(00)80434-3.
5
Effect of anti-interleukin 12 treatment on murine lyme borreliosis.抗白细胞介素12治疗对小鼠莱姆病的影响。
J Clin Invest. 1996 Feb 15;97(4):1028-34. doi: 10.1172/JCI118494.
6
Serum-mediated resolution of Lyme arthritis in mice.血清介导的小鼠莱姆关节炎的消退
Lab Invest. 1996 Jan;74(1):57-67.
7
OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection.对已感染伯氏疏螺旋体的小鼠进行OspA疫苗接种会改变疾病状况，但不会改变感染情况。
Infect Immun. 1993 Jun;61(6):2553-7. doi: 10.1128/iai.61.6.2553-2557.1993.
8
Chronic Lyme borreliosis in the laboratory mouse.实验室小鼠中的慢性莱姆病螺旋体病
Am J Pathol. 1993 Sep;143(3):959-71.
9
Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues.对严重的伯氏疏螺旋体诱导性关节炎的遗传性易感性是显性的，并且与大量螺旋体在组织中的持续存在有关。
Infect Immun. 1994 Feb;62(2):492-500. doi: 10.1128/iai.62.2.492-500.1994.
10
Target imbalance: disparity of Borrelia burgdorferi genetic material in synovial fluid from Lyme arthritis patients.靶点失衡：莱姆关节炎患者滑液中伯氏疏螺旋体遗传物质的差异
J Infect Dis. 1994 Mar;169(3):668-72. doi: 10.1093/infdis/169.3.668.
Zotero 插件