Scupi B S, Benson B E, Brown L B, Uhde T W
Unit on Anxiety Disorders, National Institute of Mental Health, NIH, Bethesda, MD 20892-1272, USA.
Depress Anxiety. 1997;5(3):121-6. doi: 10.1002/(sici)1520-6394(1997)5:3<121::aid-da2>3.0.co;2-h.
This study examined the value of the DSM-IV time criterion for panic disorder (PD) requiring an abrupt onset to panic attacks (PAs) with a time to peak intensity (TTPI) of less than 10 min, and evaluated features distinguishing rapid onset (TTPI < 10) from prolonged onset (TTPI > 10) panickers. Eight hundred and sixty-four respondents to the National Institute of Mental Health Panic Disorder Questionnaire (NIMH PQ) who met the first three PD criteria were compared based on the time criterion. The prolonged onset panickers (18.2%) did not differ significantly from rapid onset panickers (81.8%) on any of 100 items assessing clinical symptoms, course of illness, and comorbidity of PD. These results suggest that many patients with otherwise classic features of PD have a prolonged TTPI of PAs, and that patients with prolonged-onset PAs are similar to patients with rapid-onset PAs on most measures. The reliability, validity, and clinical relevance of the current DSM-IV TTPI criterion should be evaluated in future studies.
本研究考察了《精神疾病诊断与统计手册》第四版（DSM-IV）中恐慌症（PD）的时间标准的价值，该标准要求恐慌发作（PA）突然起病，且达到峰值强度的时间（TTPI）少于10分钟，并评估了区分快速起病（TTPI < 10）和缓慢起病（TTPI > 10）的恐慌症患者的特征。对符合前三项PD标准的864名美国国立精神卫生研究所恐慌症问卷（NIMH PQ）受访者，根据时间标准进行了比较。在评估PD临床症状、病程和共病情况的100个项目中的任何一项上，缓慢起病的恐慌症患者（18.2%）与快速起病的恐慌症患者（81.8%）均无显著差异。这些结果表明，许多具有典型PD特征的患者PA的TTPI较长，且在大多数指标上，缓慢起病的PA患者与快速起病的PA患者相似。当前DSM-IV的TTPI标准的可靠性、有效性和临床相关性应在未来研究中进行评估。
