钝顶螺旋藻抑制过敏反应。

Spirulina platensis inhibits anaphylactic reaction.

作者信息

Yang H N, Lee E H, Kim H M

机构信息

Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Ikasn, Chonbuk, South Korea.

出版信息

Life Sci. 1997;61(13):1237-44. doi: 10.1016/s0024-3205(97)00668-1.

DOI:10.1016/s0024-3205(97)00668-1

PMID:9324065

Abstract

We investigated the effects of the powders of Spirulina platensis (SPP) on anaphylactic reactions. SPP inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.5, and 1.0 mg/g body weight (BW). SPP significantly inhibited serum histamine levels induced by compound 48/80 in rats. SPP (0.5 mg/g BW) inhibited to 68.7% passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. SPP dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. Moreover, SPP had a significant effect on anti-DNP IgE-induced histamine release or tumor necrosis factor-alpha production from RPMC. These results suggest that SPP may contain compounds with actions that inhibit mast cell degranulation in the rat.

摘要

我们研究了钝顶螺旋藻（SPP）粉末对过敏反应的影响。剂量为0.5和1.0毫克/克体重（BW）时，SPP对化合物48/80诱导的过敏性休克的抑制率达100%。SPP显著抑制了化合物48/80诱导的大鼠血清组胺水平。SPP（0.5毫克/克BW）对由抗二硝基苯基（DNP）IgE激活的被动皮肤过敏反应的抑制率为68.7%。SPP剂量依赖性地抑制化合物48/80诱导的大鼠腹膜肥大细胞（RPMC）组胺释放。此外，SPP对RPMC中抗DNP IgE诱导的组胺释放或肿瘤坏死因子-α产生有显著影响。这些结果表明，SPP可能含有具有抑制大鼠肥大细胞脱颗粒作用的化合物。