急性播散性脑脊髓炎早期大剂量静脉注射甲基强的松龙：成功康复一例

Early high-dose intravenous methylprednisolone in acute disseminated encephalomyelitis: a successful recovery.

作者信息

Straub J, Chofflon M, Delavelle J

机构信息

Department of Internal Medicine, University Hospital of Geneva, Switzerland.

出版信息

Neurology. 1997 Oct;49(4):1145-7. doi: 10.1212/wnl.49.4.1145.

DOI:10.1212/wnl.49.4.1145

PMID:9339706

Abstract

We describe a patient with acute disseminated encephalomyelitis (ADEM) who was treated with high-dose intravenous methylprednisolone 2 days after onset of neurologic symptoms. Despite poor prognostic factors and extensive white matter lesions, the patient recovered dramatically with no need for maintenance steroid therapy. This case report of fulminant ADEM treated successfully with early high-dose intravenous methylprednisolone, although uncontrolled, suggests that this agent should be studied in other cases.

摘要

我们描述了一名急性播散性脑脊髓炎（ADEM）患者，该患者在出现神经系统症状2天后接受了大剂量静脉注射甲基强的松龙治疗。尽管存在不良预后因素且有广泛的白质病变，但患者恢复显著，无需维持性类固醇治疗。这例早期大剂量静脉注射甲基强的松龙成功治疗暴发性ADEM的病例报告，尽管未设对照，但提示该药物应在其他病例中进行研究。