新病原体的出现是宿主易感性变化的一种表现。
Emergence of new pathogens as a function of changes in host susceptibility.
作者信息
Morris J G, Potter M
机构信息
University of Maryland School of Medicine, Baltimore 21201, USA.
出版信息
Emerg Infect Dis. 1997 Oct-Dec;3(4):435-41. doi: 10.3201/eid0304.970404.
Abstract
A pathogen may emerge as an important public health problem because of changes in itself or its transmission pathways. Alternatively, a microorganism may emerge as a pathogen or acquire new public health importance because of changes in host susceptibility to infection. Factors influencing host susceptibility within the population as a whole include increases in the number of immunocompromised patients; increased use of immunosuppressive agents, particularly among persons receiving cancer chemotherapy or undergoing organ transplantation; aging of the population; and malnutrition. In considering the emergence of foodborne pathogens and designing interventions to limit their spread, the susceptibility of these population subgroups to specific infections should be taken into account.
摘要
病原体可能因其自身或其传播途径的变化而成为一个重要的公共卫生问题。或者，一种微生物可能由于宿主对感染的易感性变化而成为病原体或获得新的公共卫生重要性。影响整个人口中宿主易感性的因素包括免疫功能低下患者数量的增加；免疫抑制剂使用的增加，特别是在接受癌症化疗或进行器官移植的人群中；人口老龄化；以及营养不良。在考虑食源性病原体的出现并设计干预措施以限制其传播时，应考虑这些人群亚组对特定感染的易感性。
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