与职业性接触鱼类麻醉剂MS-222相关的视网膜毒性。
Retinal toxicity associated with occupational exposure to the fish anesthetic MS-222.
作者信息
Bernstein P S, Digre K B, Creel D J
机构信息
Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA.
出版信息
Am J Ophthalmol. 1997 Dec;124(6):843-4. doi: 10.1016/s0002-9394(14)71705-2.
PURPOSE
To report a case of retinopathy associated with chronic occupational exposure to ethyl-m-aminobenzoic acid methanesulfonate (MS-222), a retinotoxic fish anesthetic.
METHOD
Case report with electroretinograms to document changes in visual electrophysiology.
RESULTS
An ichthyologist with a long history of skin exposure to MS-222 was initially examined for decreased vision, photophobia, and photopsia. His electroretinogram abnormalities were similar to those seen in animal models of acute MS-222 toxicity. After terminating MS-222 contact for 7 months, his vision returned to normal, and his electroretinogram improved.
CONCLUSION
Individuals with occupational exposure to MS-222 should exercise caution to avoid systemic absorption of this retinotoxic compound.
目的
报告一例与长期职业性接触甲磺酸乙氧苯酰胺（MS - 222，一种具有视网膜毒性的鱼类麻醉剂）相关的视网膜病变病例。
方法
通过病例报告及视网膜电图记录视觉电生理变化。
结果
一名有长期皮肤接触MS - 222病史的鱼类学家最初因视力下降、畏光和闪光幻觉接受检查。其视网膜电图异常与急性MS - 222毒性动物模型中所见相似。在停止接触MS - 222 7个月后，他的视力恢复正常，视网膜电图也有所改善。
结论
职业性接触MS - 222的个体应谨慎行事，避免这种具有视网膜毒性的化合物发生全身吸收。
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