Arsenian M A
Cape Ann Medical Center, Gloucester, MA 01930, USA.
Prog Cardiovasc Dis. 1997 Nov-Dec;40(3):265-86. doi: 10.1016/s0033-0620(97)80037-0.
Carnitine and its derivative propionyl-L-carnitine are endogenous cofactors which enhance carbohydrate metabolism and reduce the intracellular buildup of toxic metabolites in ischemic conditions. The carnitines have been, and are being used in a spectrum of diseases including multiple cardiovascular conditions. These include angina, acute myocardial infarction, postmyocardial infarction, congestive heart failure, peripheral vascular disease, dyslipidemia, and diabetes. Most published data on carnitine, propionyl-L-carnitine, and other carnitine congeners are favorable but the clinical trials have been relatively small. In currently used doses, these substances are virtually devoid of significant side effects.
肉碱及其衍生物丙酰-L-肉碱是内源性辅助因子，可增强碳水化合物代谢，并减少缺血状态下细胞内有毒代谢物的积累。肉碱已被用于，并且正在用于一系列疾病，包括多种心血管疾病。这些疾病包括心绞痛、急性心肌梗死、心肌梗死后、充血性心力衰竭、外周血管疾病、血脂异常和糖尿病。关于肉碱、丙酰-L-肉碱和其他肉碱同系物的大多数已发表数据都是有利的，但临床试验规模相对较小。在目前使用的剂量下，这些物质几乎没有明显的副作用。
