智利菊科拟鼠麴草属植物树脂状渗出物以及从中分离出的二萜类化合物和黄酮类化合物的抗菌研究。

Antimicrobial study of the resinous exudates and of diterpenoids and flavonoids isolated from some Chilean Pseudognaphalium (Asteraceae).

作者信息

Mendoza L, Wilkens M, Urzúa A

机构信息

Departamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile.

出版信息

J Ethnopharmacol. 1997 Oct;58(2):85-8. doi: 10.1016/s0378-8741(97)00084-6.

DOI:10.1016/s0378-8741(97)00084-6

PMID:9406895

Abstract

The antimicrobial properties of the resinous exudates from twigs and leaves of four Chilean species of Pseudognaphalium: P. viravira, P. robustum, P. heterotrichium and P. cheiranthifolium were tested against six gram negative bacteria and five gram positive bacteria. The extracts share similar antimicrobial activities against the gram positive bacteria. The antimicrobial activity correlated very well with the presence in the resinous exudates of ent-16-kauren-19-oic acid and to a lesser extent with the presence of ent-9(11),16-kauradien-19-oic. Introduction of an hydrophilic 3 beta-OH drastically reduced the antimicrobial activity of these compound. The activity was not correlated with the flavonoid content of those resinous exudates.

摘要

对四种智利鼠麴草属植物（维氏鼠麴草、粗壮鼠麴草、异毛鼠麴草和桂叶鼠麴草）嫩枝和叶片的树脂状渗出物的抗菌特性进行了测试，受试对象为六种革兰氏阴性菌和五种革兰氏阳性菌。这些提取物对革兰氏阳性菌具有相似的抗菌活性。抗菌活性与树脂状渗出物中ent-16-贝壳杉烷-19-酸的存在密切相关，与ent-9(11),16-贝壳杉二烯-19-酸的存在相关性较小。引入亲水性的3β-OH会大幅降低这些化合物的抗菌活性。该活性与那些树脂状渗出物的黄酮含量无关。