Jain S C, Jain R, Sharma R A, Capasso F
Department of Botany, University of Rajasthan, Jaipur, India.
J Ethnopharmacol. 1997 Oct;58(2):135-42. doi: 10.1016/s0378-8741(97)00091-3.
In the present study, the ethanolic extract of the whole plant parts (root, stem leaves and pods) of Cassia italica (Mill.) Lam. ex F.W. Ander (Leguminosae) was investigated for bioactivities: namely anti-inflammatory, antipyretic, analgesic and prostaglandin (PG) release by rat peritoneal leucocytes, antineoplastic and antiviral. In rats, the extracts reduced carrageenin-induced paw swelling (100 mg/kg bw-31%) and fever (100 mg/kg bw-37%). The extract showed weak effect on writhing induced by acetic acid. A dose-dependent inhibition of PG release effect was observed using rat peritoneal leucocytes.
在本研究中，对意大利决明（Cassia italica (Mill.) Lam. ex F.W. Ander，豆科）全株各部分（根、茎叶和豆荚）的乙醇提取物进行了生物活性研究：即抗炎、解热、镇痛以及对大鼠腹腔白细胞释放前列腺素（PG）的影响、抗肿瘤和抗病毒活性。在大鼠实验中，提取物可减轻角叉菜胶诱导的爪肿胀（100 mg/kg体重 - 减轻31%）和发热（100 mg/kg体重 - 降低37%）。提取物对醋酸诱导的扭体反应显示出较弱的作用。使用大鼠腹腔白细胞观察到提取物对PG释放效应有剂量依赖性抑制作用。
