意大利决明的药理学研究。

Pharmacological investigation of Cassia italica.

作者信息

Jain S C, Jain R, Sharma R A, Capasso F

机构信息

Department of Botany, University of Rajasthan, Jaipur, India.

出版信息

J Ethnopharmacol. 1997 Oct;58(2):135-42. doi: 10.1016/s0378-8741(97)00091-3.

DOI:10.1016/s0378-8741(97)00091-3

PMID:9406903

Abstract

In the present study, the ethanolic extract of the whole plant parts (root, stem leaves and pods) of Cassia italica (Mill.) Lam. ex F.W. Ander (Leguminosae) was investigated for bioactivities: namely anti-inflammatory, antipyretic, analgesic and prostaglandin (PG) release by rat peritoneal leucocytes, antineoplastic and antiviral. In rats, the extracts reduced carrageenin-induced paw swelling (100 mg/kg bw-31%) and fever (100 mg/kg bw-37%). The extract showed weak effect on writhing induced by acetic acid. A dose-dependent inhibition of PG release effect was observed using rat peritoneal leucocytes.

摘要

在本研究中，对意大利决明（Cassia italica (Mill.) Lam. ex F.W. Ander，豆科）全株各部分（根、茎叶和豆荚）的乙醇提取物进行了生物活性研究：即抗炎、解热、镇痛以及对大鼠腹腔白细胞释放前列腺素（PG）的影响、抗肿瘤和抗病毒活性。在大鼠实验中，提取物可减轻角叉菜胶诱导的爪肿胀（100 mg/kg体重 - 减轻31%）和发热（100 mg/kg体重 - 降低37%）。提取物对醋酸诱导的扭体反应显示出较弱的作用。使用大鼠腹腔白细胞观察到提取物对PG释放效应有剂量依赖性抑制作用。