Krawczynski K
Hepatitis Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
J Gastroenterol Hepatol. 1997 Oct;12(9-10):S193-4. doi: 10.1111/j.1440-1746.1997.tb00501.x.
A new virus with genomic organization similar to that of the family Flaviviridae was identified in patients with viral hepatitis and designated hepatitis G virus (HGV) or hepatitis GB virus C (GBV-C). HGV/GBV-C can be transmitted by blood and results in persistent infection, as shown in patients with posttransfusion non-A, non-B hepatitis, in transfusion recipients, and in donors of blood received by HGV-positive patients. The parenteral route of transmission of HGV/GBV-C infection was confirmed in experimentally infected chimpanzees. Epidemiologic studies of sporadic, community-acquired viral hepatitis have not indicated an association between HGV/GBV-C and acute non A-E hepatitis. Thus, the disease association of this new virus remains unconfirmed and its role in the etiology of acute and chronic hepatitis is unclear. The experimental model of HGV/GBV-C infection may define the biology of the virus replication.
在病毒性肝炎患者中发现了一种基因组结构与黄病毒科相似的新型病毒，被命名为庚型肝炎病毒（HGV）或GB病毒C型（GBV-C）。HGV/GBV-C可通过血液传播并导致持续感染，这在输血后非甲非乙型肝炎患者、输血受者以及接受HGV阳性患者血液的献血者中得到了证实。在实验感染的黑猩猩中证实了HGV/GBV-C感染的肠道外传播途径。散发性社区获得性病毒性肝炎的流行病学研究并未表明HGV/GBV-C与急性非甲-戊型肝炎之间存在关联。因此，这种新型病毒与疾病的关联尚未得到证实，其在急慢性肝炎病因学中的作用尚不清楚。HGV/GBV-C感染的实验模型可能会明确病毒复制的生物学特性。
