Ikezaki K, Han D H, Kawano T, Inamura T, Fukui M
Department of Neurosurgery, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Clin Neurol Neurosurg. 1997 Oct;99 Suppl 2:S6-10. doi: 10.1016/s0303-8467(97)00032-2.
To both clarify the current clinico-epidemiological features of Moyamoya disease in Korea as well as compare these cases with Japanese patients, 451 cases were collected from 26 Korean major neurosurgical institutes and 296 definite cases were analyzed statistically. Although the Korean age distribution patterns of Moyamoya disease showed two peaks, similar to Japanese patients, the Korean pattern was shifted to the right thus indicating Korean adult population to be 20% higher than that of Japanese patients. The female/male ratio was 1:3, which was slightly less than that for Japanese. The family occurrence rate in Koreans was 1.8%. The incidence of cerebral infarction and bleeding in Koreans was higher while transient ischemic attack (TIA) and seizure were less than that of Japanese. The incidence of infarction in children and of hemorrhage in children and adults were also statistically higher in Koreans. The incidence of hemorrhage was higher in females than in males. Both the age at onset and sex affected the disease type. Single encephalo-duro-arterio-synangiosis (EDAS) was performed on 87.6% of all surgical cases. Although the incidence of bleeding was higher in Korea, the outcomes of the patients were similar to that of the Japanese patients. Although Korean Moyamoya disease showed a relatively higher incidence of hemorrhage and adult onset, the overall clinical background was similar to that of Japanese patients.
为了阐明韩国烟雾病当前的临床流行病学特征，并将这些病例与日本患者进行比较，我们从韩国26家主要神经外科机构收集了451例病例，并对296例确诊病例进行了统计分析。虽然韩国烟雾病的年龄分布模式与日本患者相似，呈现两个高峰，但韩国的模式向右偏移，这表明韩国成年人口比日本患者高20%。女性/男性比例为1:3，略低于日本。韩国人的家族发病率为1.8%。韩国人脑梗死和出血的发生率较高，而短暂性脑缺血发作（TIA）和癫痫发作的发生率低于日本人。韩国儿童梗死的发生率以及儿童和成人出血的发生率在统计学上也更高。女性出血的发生率高于男性。发病年龄和性别都会影响疾病类型。所有手术病例中有87.6%进行了单脑硬膜动脉血管吻合术（EDAS）。虽然韩国出血的发生率较高，但患者的预后与日本患者相似。虽然韩国烟雾病出血和成人发病的发生率相对较高，但其总体临床背景与日本患者相似。
